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Image Search Results
Journal: Scientific Reports
Article Title: Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors
doi: 10.1038/s41598-017-14203-4
Figure Lengend Snippet: ( A ) Effect of delta-9-THC on activation relative to placebo in the right amygdala (cross-hairs) while subjects viewed fearful relative to neutral facial stimuli ( p = 0.0004, corrected for <1 false-positive cluster; peak focus x = 29, y = 4, z = −13, coordinates in Talairach space). ( B ) Plot showing the mean magnitude of activation (indexed by the sum of squares ratio, y-axis; error bars show standard error of the mean) in the right amygdala following administration of delta-9-THC and placebo, respectively. ( C ) Image showing CB1 receptor availability in the amygdala (encircled) assessed using [ 11 C]MePPEP PET [Mean (SD) CB1 V T in right amygdala: 12.57 (3.27) ml/g; Range: 7.51–17.75 ml/g]. ( D ) Correlation between the anxiety symptoms induced by delta-9-THC and CB1 V T in the right amygdala. ( E ) Direct correlation between the effect of delta-9-THC on the right amygdalar response while subjects viewed fearful faces and CB1 V T in the right amygdala.
Article Snippet: [ 11
Techniques: Activation Assay